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Death may result from several pathologies that deviate from benign laughter. Infarction of the pons and medulla oblongata in the brain may cause pathological laughter. Laughter can cause atonia and collapse ("gelastic syncope") which in turn can cause trauma. See also laughter-induced syncope, cataplexy, and Bezold-Jarisch reflex. Gelastic seizures can be due to focal lesions to the hypothalamus.

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Death may result from several pathologies that deviate from benign laughter. Infarction of the pons and medulla oblongata in the brain may cause pathological laughter. Laughter can cause atonia and collapse ("gelastic syncope") which in turn can cause trauma. See also laughter-induced syncope, cataplexy, and Bezold-Jarisch reflex. Gelastic seizures can be due to focal lesions to the hypothalamus.


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